Item name:
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Группа:
Intermediates
Номер CAS:
1421373-65-0
Синонимы:
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Молекулярная формула:
C28H33N7O2
Молекулярный вес:
499.6 г/моль
На текущий момент информация отсутствует
Supplier(s): 17
Univar Solutions GmbH
Germany
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Product Name: AZD-9291
Synonyms: N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide;AZD929/Osimertinib;Osimertinib Intermediate 4;Osimertinib, 98%, a potent and selective mutated forms EGFR inhibitor;Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0;Mereletinib;N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;Mereletinib mesylate(AZD9291)
CAS: 1421373-65-0
MF: C28H33N7O2
MW: 499.61
EINECS: 629-848-5
Product Categories: Inhibitors;API;AZD9291;Anticancer
Mol File: 1421373-65-0.mol
Pharmaceutics
99%
TT Advance
CIF
SUZHOU, CHINA
Приложение:
AZD-9291 (Osimertinib) is a oral, third generation, small-molecule epidermal growth factor receptor (EGFR) inhibitor and antineoplastic agent. In addition, it is a Cytochrome P450 3A inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 1A2 Inducer, and Breast Cancer Resistance Protein Inhibitor. It is used for the treatment of advanced non-small cell lung cancer (NSCLC) where mutant EGFR form (such as T790M) is often presented. Through suppressing the EGFR-mediated signalling, it cause cell death and inhibit tumour growth in related cancer cells.
Доступна отправка
Shin-Etsu
United States
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Radchem Products, Inc.
United States
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
RT VANDERBILT HOLDING CO INC
United States
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
OQEMA
Germany
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Nanjing Lanya Chemical
China
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Matrix Fine Chemicals GmbH
Switzerland
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Julius Hoesch GmbH & Co. KG
Germany
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
INTEGRATED TRAFFIC SYSTEMS INC
United States
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Chemicals United B.V.
Netherlands
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Bazayan & Co
India
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
BCD Chemie GmbH
Germany
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
Apollo Scientific LTD
United Kingdom
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
ALL Chemistry Inc.
United States
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
Доступна отправка
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